Evidence for the Role of Histamine H3 Receptor in Alcohol Consumption and Alcohol Reward in Mice
Copyright policy )Evidence for the Role of Histamine H3 Receptor in Alcohol Consumption and Alcohol Reward in Mice
Recent research suggests that histamine H3 receptor (H3R) antagonism may diminish motivational aspects of alcohol dependence. We studied the role of H3Rs in alcohol-related behaviors using H3R knockout (KO) mice and ligands. H3R KO mice consumed less alcohol than wild-type (WT) mice in a two-bottle free-choice test and in a 'drinking in the dark' model. H3R antagonist ciproxifan suppressed and H3R agonist immepip increased alcohol drinking in C57BL/6J mice. Impairment in reward mechanisms in H3R KO mice was confirmed by the lack of alcohol-evoked conditioned place preference. Plasma alcohol concentrations of H3R KO and WT mice were similar. There were no marked differences in brain biogenic amine levels in H3R KO mice compared with the control animals after alcohol drinking. In conclusion, the findings of this study provide evidence for the role of H3R receptor in alcohol-related behaviors, especially in alcohol drinking and alcohol reward. Thus, targeting H3Rs with a specific antagonist might be a potential means to treat alcoholism in the future.
- Helsinki University Hospital Finland
- Åbo Akademi University Finland
- University of Helsinki Finland
Male, Mice, Knockout, Mice, 129 Strain, Alcohol Drinking, Ethanol, Dopamine, Addiction & Substance Abuse, drinking in the dark, two-bottle choice test, histamine, Alcohol & Alcoholism, Animal models, Histamine Agonists, Mice, Inbred C57BL, Mice, Random Allocation, Reward, Gene Targeting, Animals, Receptors, Histamine H3, Histamine H3 Antagonists
Male, Mice, Knockout, Mice, 129 Strain, Alcohol Drinking, Ethanol, Dopamine, Addiction & Substance Abuse, drinking in the dark, two-bottle choice test, histamine, Alcohol & Alcoholism, Animal models, Histamine Agonists, Mice, Inbred C57BL, Mice, Random Allocation, Reward, Gene Targeting, Animals, Receptors, Histamine H3, Histamine H3 Antagonists
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).50 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!