A novel dendritic cell subset involved in tumor immunosurveillance
Copyright policy )A novel dendritic cell subset involved in tumor immunosurveillance
The interferon (IFN)-gamma-induced TRAIL effector mechanism is a vital component of cancer immunosurveillance by natural killer (NK) cells in mice. Here we show that the main source of IFN-gamma is not the conventional NK cell but a subset of B220(+)Ly6C(-) dendritic cells, which are atypical insofar as they express NK cell-surface molecules. Upon contact with a variety of tumor cells that are poorly recognized by NK cells, B220(+)NK1.1(+) dendritic cells secrete high levels of IFN-gamma and mediate TRAIL-dependent lysis of tumor cells. Adoptive transfer of these IFN-producing killer dendritic cells (IKDCs) into tumor-bearing Rag2(-/-)Il2rg(-/-) mice prevented tumor outgrowth, whereas transfer of conventional NK cells did not. In conclusion, we identified IKDCs as pivotal sensors and effectors of the innate antitumor immune response.
- Institut Gustave Roussy France
- Institute Curie France
- Assistance Publique -Hopitaux De Paris France
- Pitié-Salpêtrière Hospital France
- Aix-Marseille University France
Cytotoxicity, Immunologic, Antigen Presentation, Mice, Inbred BALB C, Membrane Glycoproteins, [SDV.IMM] Life Sciences [q-bio]/Immunology, Dendritic Cells, Adoptive Transfer, CD11c Antigen, DNA-Binding Proteins, Killer Cells, Natural, Interferon-gamma, Mice, Cell Line, Tumor, Antigens, Surface, Animals, Antigens, Ly, Leukocyte Common Antigens, Female, Lectins, C-Type, Apoptosis Regulatory Proteins, Interleukin Receptor Common gamma Subunit
Cytotoxicity, Immunologic, Antigen Presentation, Mice, Inbred BALB C, Membrane Glycoproteins, [SDV.IMM] Life Sciences [q-bio]/Immunology, Dendritic Cells, Adoptive Transfer, CD11c Antigen, DNA-Binding Proteins, Killer Cells, Natural, Interferon-gamma, Mice, Cell Line, Tumor, Antigens, Surface, Animals, Antigens, Ly, Leukocyte Common Antigens, Female, Lectins, C-Type, Apoptosis Regulatory Proteins, Interleukin Receptor Common gamma Subunit
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