Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement
Copyright policy )Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement
Polycomb group protein Ezh2 is an essential epigenetic regulator of embryonic development in mice, but its role in the adult organism is unknown. High expression of Ezh2 in developing murine lymphocytes suggests Ezh2 involvement in lymphopoiesis. Using Cre-mediated conditional mutagenesis, we demonstrated a critical role for Ezh2 in early B cell development and rearrangement of the immunoglobulin heavy chain gene (Igh). We also revealed Ezh2 as a key regulator of histone H3 methylation in early B cell progenitors. Our data suggest Ezh2-dependent histone H3 methylation as a novel regulatory mechanism controlling Igh rearrangement during early murine B cell development.
- Columbia University United States
- King’s University United States
- Max Planck Society Germany
- Max Planck Institute of Biochemistry Germany
- Rockefeller University United States
Mice, Knockout, B-Lymphocytes, Gene Rearrangement, B-Lymphocyte, Heavy Chain, Gene Expression Regulation, Developmental, Polycomb-Group Proteins, Cell Differentiation, Mice, Transgenic, Milk Proteins, Methylation, DNA-Binding Proteins, Histones, Repressor Proteins, Mice, Mutagenesis, STAT5 Transcription Factor, Trans-Activators, Animals
Mice, Knockout, B-Lymphocytes, Gene Rearrangement, B-Lymphocyte, Heavy Chain, Gene Expression Regulation, Developmental, Polycomb-Group Proteins, Cell Differentiation, Mice, Transgenic, Milk Proteins, Methylation, DNA-Binding Proteins, Histones, Repressor Proteins, Mice, Mutagenesis, STAT5 Transcription Factor, Trans-Activators, Animals
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