Birth and adaptive evolution of a hominoid gene that supports high neurotransmitter flux
Copyright policy )Birth and adaptive evolution of a hominoid gene that supports high neurotransmitter flux
The enzyme glutamate dehydrogenase (GDH) is important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission. Human GDH exists in housekeeping and brain-specific isotypes encoded by the genes GLUD1 and GLUD2, respectively. Here we show that GLUD2 originated by retroposition from GLUD1 in the hominoid ancestor less than 23 million years ago. The amino acid changes responsible for the unique brain-specific properties of the enzyme derived from GLUD2 occurred during a period of positive selection after the duplication event.
- University of Lausanne Switzerland
- Science for Life Laboratory Sweden
Neurotransmitter Agents, Time Factors, Retroelements, Brain, Hominidae, Evolution, Molecular, Isoenzymes, Glutamate Dehydrogenase, Gene Duplication, Animals, Humans, Selection, Genetic, Phylogeny
Neurotransmitter Agents, Time Factors, Retroelements, Brain, Hominidae, Evolution, Molecular, Isoenzymes, Glutamate Dehydrogenase, Gene Duplication, Animals, Humans, Selection, Genetic, Phylogeny
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).176 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
Citations provided by BIP!Popularity provided by BIP!