<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=undefined&type=result"></script>');
-->
</script>

COPY SCRIPT

For further information contact us at helpdesk@openaire.eu

Spontaneous X chromosome MI and MII nondisjunction events in Drosophila melanogaster oocytes have different recombinational histories

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 1996 English Publisher:Springer Science and Business Media LLCJournal:Nature Genetics, volume 14, pages 406-414 (issn: 1061-4036, eissn: 1546-1718,

Authors: K C Herman; H E Collins; RS Hawley; Rachael L French; Schuetz Cd; K E Koehler; LD Madden; +2 Authors

doi: 10.1038/ng1296-406

pmid: 8944020

Spontaneous X chromosome MI and MII nondisjunction events in Drosophila melanogaster oocytes have different recombinational histories

- Summary
- Subjects
- Related research
  (14)
- Metrics

tips_and_updates
Recommended

Abstract

Recent studies of human oocytes have demonstrated an enrichment for distal exchanges among meiosis I (MI) nondisjunction events and for proximal exchanges among meiosis II (MII) events. Our characterization of 103 cases of spontaneous X chromosome nondisjunction in Drosophila oocytes strongly parallels these observations. The recombinational histories of MI (97/103) and MII (6/103) nondisjunctional ova were strikingly different. MI nondisjunction occurred primarily in oocytes with non-exchange X chromosomes; of the new nondisjoining exchange bivalents, most carried distal crossovers. Thus, spontaneous MI nondisjunction reflects the failure of the achiasmate segregation systems. MII nondisjunction occurred only in oocytes with proximal exchanges. We propose several models to explain how very proximal exchanges might impair proper segregation.

Related Organizations

University of California, Davis
United States

Keywords

Genetic Markers, Male, Recombination, Genetic, X Chromosome, Centromere, Mitosis, Meiosis, Nondisjunction, Genetic, Heterochromatin, Oocytes, Animals, Humans, Drosophila, Female, Crosses, Genetic

14 Research products, page 1 of 2

Tryptophan 2,3-dioxygenase
2017IsRelatedTo
Carnation, isoform B
2017IsRelatedTo
Protein suppressor of forked
2017IsRelatedTo
Vermilion
2017IsRelatedTo
Vacuolar protein sorting-associated protein 33A
2017IsRelatedTo
Vermilion
2017IsRelatedTo
Carnation, isoform C
2017IsRelatedTo
Vermilion
2017IsRelatedTo
Vermilion
2017IsRelatedTo
Vermilion
2017IsRelatedTo

chevron_left
1
2
chevron_right

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	135
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%