Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci
Copyright policy )Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci
Behçet's disease is a chronic systemic inflammatory disorder characterized by four major manifestations: recurrent ocular symptoms, oral and genital ulcers and skin lesions. We conducted a genome-wide association study in a Japanese cohort including 612 individuals with Behçet's disease and 740 unaffected individuals (controls). We identified two suggestive associations on chromosomes 1p31.3 (IL23R-IL12RB2, rs12119179, P = 2.7 x 10(-8)) and 1q32.1 (IL10, rs1554286, P = 8.0 x 10(-8)). A meta-analysis of these two loci with results from additional Turkish and Korean cohorts showed genome-wide significant associations (rs1495965 in IL23R-IL12RB2, P = 1.9 x 10(-11), odds ratio = 1.35; rs1800871 in IL10, P = 1.0 x 10(-14), odds ratio = 1.45).
- Shinshu University Japan
- Shinshu University Japan
- Seoul National University Korea (Republic of)
- Hokkaido University Japan
- Hokkaido Bunkyo University Japan
Turkey, Behcet Syndrome, Eye, Skin Diseases, Interleukin-10, Case-Control Studies, Odds Ratio, Humans, Disease Susceptibility, Genome-Wide Association Study
Turkey, Behcet Syndrome, Eye, Skin Diseases, Interleukin-10, Case-Control Studies, Odds Ratio, Humans, Disease Susceptibility, Genome-Wide Association Study
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