Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm
Copyright policy )Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm
We performed a genome-wide association study on 1,292 individuals with abdominal aortic aneurysms (AAAs) and 30,503 controls from Iceland and The Netherlands, with a follow-up of top markers in up to 3,267 individuals with AAAs and 7,451 controls. The A allele of rs7025486 on 9q33 was found to associate with AAA, with an odds ratio (OR) of 1.21 and P = 4.6 x 10(-10). In tests for association with other vascular diseases, we found that rs7025486[A] is associated with early onset myocardial infarction (OR = 1.18, P = 3.1 x 10(-5)), peripheral arterial disease (OR = 1.14, P = 3.9 x 10(-5)) and pulmonary embolism (OR = 1.20, P = 0.00030), but not with intracranial aneurysm or ischemic stroke. No association was observed between rs7025486[A] and common risk factors for arterial and venous diseases-that is, smoking, lipid levels, obesity, type 2 diabetes and hypertension. Rs7025486 is located within DAB2IP, which encodes an inhibitor of cell growth and survival.
- University of Pittsburgh United States
- University of Liège Belgium
- Emory University United States
- University of Pennsylvania United States
- University of Iceland Iceland
HOMEOSTASIS, Iceland, Myocardial Infarction, 610, DAB2IP gene; abdominal aortic aneurysm, Sciences de la santé humaine, IGMD 6: Hormonal regulation, FAMILY-HISTORY, DISEASE, abdominal aortic aneurysm, 9P21, Risk Factors, LOCUS, LINKAGE, Odds Ratio, GWAS, Humans, Abdominal, NCEBP 2: Evaluation of complex medical interventions, Human health sciences, Chirurgie, Alleles, Netherlands, RISK, NCEBP 6: Quality of nursing and allied health care, VENOUS THROMBOEMBOLISM, Base Sequence, ARTERIAL, NCEBP 1: Molecular epidemiology, ONCOL 5: Aetiology, screening and detection, Aortic Aneurysm, MYOCARDIAL-INFARCTION, ras GTPase-Activating Proteins, Hypertension, Surgery, Disease Susceptibility, IGMD 5: Health aging / healthy living, Aortic Aneurysm, Abdominal, Genome-Wide Association Study
HOMEOSTASIS, Iceland, Myocardial Infarction, 610, DAB2IP gene; abdominal aortic aneurysm, Sciences de la santé humaine, IGMD 6: Hormonal regulation, FAMILY-HISTORY, DISEASE, abdominal aortic aneurysm, 9P21, Risk Factors, LOCUS, LINKAGE, Odds Ratio, GWAS, Humans, Abdominal, NCEBP 2: Evaluation of complex medical interventions, Human health sciences, Chirurgie, Alleles, Netherlands, RISK, NCEBP 6: Quality of nursing and allied health care, VENOUS THROMBOEMBOLISM, Base Sequence, ARTERIAL, NCEBP 1: Molecular epidemiology, ONCOL 5: Aetiology, screening and detection, Aortic Aneurysm, MYOCARDIAL-INFARCTION, ras GTPase-Activating Proteins, Hypertension, Surgery, Disease Susceptibility, IGMD 5: Health aging / healthy living, Aortic Aneurysm, Abdominal, Genome-Wide Association Study
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