Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations
Copyright policy )Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations
We analyzed genome-wide association data from 1,380 Europeans with early-onset and morbid adult obesity and 1,416 age-matched normal-weight controls. Thirty-eight markers showing strong association were further evaluated in 14,186 European subjects. In addition to FTO and MC4R, we detected significant association of obesity with three new risk loci in NPC1 (endosomal/lysosomal Niemann-Pick C1 gene, P = 2.9 x 10(-7)), near MAF (encoding the transcription factor c-MAF, P = 3.8 x 10(-13)) and near PTER (phosphotriesterase-related gene, P = 2.1 x 10(-7)).
- University of Oxford United Kingdom
- University of Queensland Australia
- University of Lille France
- University of Oulu Finland
- McGill University Canada
Adult, [SDV]Life Sciences [q-bio], Population, Quantitative Trait Loci, 610, Alpha-Ketoglutarate-Dependent Dioxygenase FTO, Polymorphism, Single Nucleotide, 1311 Genetics, Gene Frequency, Niemann-Pick C1 Protein, 616, Humans, Genetic Predisposition to Disease, Age of Onset, Child, Genetics & Heredity, Membrane Glycoproteins, Intracellular Signaling Peptides and Proteins, Proteins, Obesity, Morbid, [SDV] Life Sciences [q-bio], Europe, Case-Control Studies, Proto-Oncogene Proteins c-maf, Carrier Proteins, Genome-Wide Association Study
Adult, [SDV]Life Sciences [q-bio], Population, Quantitative Trait Loci, 610, Alpha-Ketoglutarate-Dependent Dioxygenase FTO, Polymorphism, Single Nucleotide, 1311 Genetics, Gene Frequency, Niemann-Pick C1 Protein, 616, Humans, Genetic Predisposition to Disease, Age of Onset, Child, Genetics & Heredity, Membrane Glycoproteins, Intracellular Signaling Peptides and Proteins, Proteins, Obesity, Morbid, [SDV] Life Sciences [q-bio], Europe, Case-Control Studies, Proto-Oncogene Proteins c-maf, Carrier Proteins, Genome-Wide Association Study
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