A new meiosis‐specific cohesin complex implicated in the cohesin code for homologous pairing
Copyright policy )A new meiosis‐specific cohesin complex implicated in the cohesin code for homologous pairing
We identify a new mammalian cohesin subunit, RAD21‐like protein (RAD21L), with sequence similarity to RAD21 and REC8. RAD21L localizes along axial elements in early meiotic prophase, in a manner that is spatiotemporally different to either REC8 or RAD21. Remarkably, RAD21L and REC8 have symmetrical, mutually exclusive localization on the not‐yet‐synapsed homologues, implying that the cohesin patterning could provide a code for homologue recognition. RAD21 transiently localizes to axial elements after the dissociation of RAD21L and REC8 in late pachytene, a period of recombination repair. Further, we show that the removal of cohesins and synaptonemal complex during late meiotic prophase is promoted by Polo‐like kinase 1, which is similar to the mitotic prophase pathway.
- University of Tokyo Japan
Chromosomal Proteins, Non-Histone, Scientific Reports, Centromere, Molecular Sequence Data, Nuclear Proteins, Cell Cycle Proteins, Protein Serine-Threonine Kinases, Phosphoproteins, Chromosomes, Mammalian, Prophase, Mass Spectrometry, DNA-Binding Proteins, Chromosome Pairing, Meiosis, Mice, Protein Subunits, Chromosome Segregation, Proto-Oncogene Proteins, Animals, Amino Acid Sequence, Chromatography, Liquid
Chromosomal Proteins, Non-Histone, Scientific Reports, Centromere, Molecular Sequence Data, Nuclear Proteins, Cell Cycle Proteins, Protein Serine-Threonine Kinases, Phosphoproteins, Chromosomes, Mammalian, Prophase, Mass Spectrometry, DNA-Binding Proteins, Chromosome Pairing, Meiosis, Mice, Protein Subunits, Chromosome Segregation, Proto-Oncogene Proteins, Animals, Amino Acid Sequence, Chromatography, Liquid
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