hnRNP Q regulates translation of p53 in normal and stress conditions
Copyright policy )hnRNP Q regulates translation of p53 in normal and stress conditions
The responses to numerous stress signals are important for cellular growth and survival. The p53 tumor-suppressor protein is stabilized under stress conditions and induces transcription of several genes to regulate cell cycle and apoptosis. Regarding p53 protein accumulation, inhibition of proteasomal degradation of p53 protein, which is mainly mediated by Mdm2, has received much attention. Here, we demonstrate that regulation of translation initiation is also crucial for p53 protein accumulation. Furthermore, we report that heterogeneous nuclear ribonucleoprotein (hnRNP) Q binds to the 5'-untranslated region (UTR) of mouse p53 mRNA and regulates translation efficiency of p53 and apoptosis progression. We also suggest that changes in cytosolic hnRNP Q levels contribute to cell cycle-dependent translational differences in p53 mRNA.
- Pohang University of Science and Technology Korea (Republic of)
p53, CIRCADIAN OSCILLATION, Cytoplasm, translation, Apoptosis, Heterogeneous-Nuclear Ribonucleoproteins, Mice, IRES, Animals, Humans, RNA, Messenger, RNA, Small Interfering, hnRNP Q, NITRIC-OXIDE, APOPTOSIS, Kinetics, IRES-MEDIATED TRANSLATION, DNA-DAMAGE, Gene Expression Regulation, CELLS, PROTEIN-SYNTHESIS, NIH 3T3 Cells, RNA Interference, CELLULAR TUMOR-ANTIGEN, Tumor Suppressor Protein p53, MESSENGER-RNA, 5' Untranslated Regions, GROWTH ARREST
p53, CIRCADIAN OSCILLATION, Cytoplasm, translation, Apoptosis, Heterogeneous-Nuclear Ribonucleoproteins, Mice, IRES, Animals, Humans, RNA, Messenger, RNA, Small Interfering, hnRNP Q, NITRIC-OXIDE, APOPTOSIS, Kinetics, IRES-MEDIATED TRANSLATION, DNA-DAMAGE, Gene Expression Regulation, CELLS, PROTEIN-SYNTHESIS, NIH 3T3 Cells, RNA Interference, CELLULAR TUMOR-ANTIGEN, Tumor Suppressor Protein p53, MESSENGER-RNA, 5' Untranslated Regions, GROWTH ARREST
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