A Role for Neuregulin1 Signaling in Muscle Spindle Differentiation
Copyright policy )A Role for Neuregulin1 Signaling in Muscle Spindle Differentiation
The maturation of synaptic structures depends on inductive interactions between axons and their prospective targets. One example of such an interaction is the influence of proprioceptive sensory axons on the differentiation of muscle spindles. We have monitored the expression of three transcription factors, Egr3, Pea3, and Erm, that delineate early muscle spindle development in an assay of muscle spindle-inducing signals. We provide genetic evidence that Neuregulin1 (Nrg1) is required for proprioceptive afferent-evoked induction of muscle spindle differentiation in the mouse. Ig-Nrg1 isoforms are preferentially expressed by proprioceptive sensory neurons and are sufficient to induce muscle spindle differentiation in vivo, whereas CRD-Nrg1 isoforms are broadly expressed in sensory and motor neurons but are not required for muscle spindle induction.
- King’s University United States
- Helmholtz Association of German Research Centres Germany
- University of Chicago United States
- Friedrich Miescher Institute Switzerland
- Max Delbrück Center for Molecular Medicine Germany
Male, Mice, Knockout, Motor Neurons, Neuroscience(all), Neuregulin-1, Gene Expression Regulation, Developmental, Cell Differentiation, Proprioception, DNA-Binding Proteins, Mice, Fetus, Ganglia, Spinal, Mutation, Animals, Protein Isoforms, Female, Neurons, Afferent, Muscle, Skeletal, Early Growth Response Protein 3, Muscle Spindles, Signal Transduction
Male, Mice, Knockout, Motor Neurons, Neuroscience(all), Neuregulin-1, Gene Expression Regulation, Developmental, Cell Differentiation, Proprioception, DNA-Binding Proteins, Mice, Fetus, Ganglia, Spinal, Mutation, Animals, Protein Isoforms, Female, Neurons, Afferent, Muscle, Skeletal, Early Growth Response Protein 3, Muscle Spindles, Signal Transduction
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