GEF what? Dock180 and related proteins help Rac to polarize cells in new ways
Copyright policy )GEF what? Dock180 and related proteins help Rac to polarize cells in new ways
Rho GTPase activation, which is mediated by guanine nucleotide exchange factors (GEFs), is tightly regulated in time and space. Although Rho GTPases have a significant role in many biological events, they are best known for their ability to restructure the actin cytoskeleton profoundly through the activation of specific downstream effectors. Two distinct families of GEFs for Rho GTPases have been reported so far, based on the features of their catalytic domains: firstly, the classical GEFs, which contain a Dbl homology-pleckstrin homology domain module with GEF activity, and secondly, the Dock180-related GEFs, which contain a Dock homology region-2 domain that catalyzes guanine nucleotide exchange on Rho GTPases. Recent exciting data suggest key roles for the DHR-2 domain-containing GEFs in a wide variety of fundamentally important biological functions, including cell migration, phagocytosis of apoptotic cells, myoblast fusion and neuronal polarization.
- University of Montreal Canada
- Montreal Clinical Research Institute Canada
- Sanford Burnham Prebys Medical Discovery Institute United States
Cell Membrane, Cell Polarity, Models, Biological, Protein Structure, Tertiary, rac GTP-Binding Proteins, Cell Fusion, Cytoskeletal Proteins, Phosphatidylinositol Phosphates, Multiprotein Complexes, Animals, Drosophila Proteins, Humans, Adaptor Proteins, Signal Transducing
Cell Membrane, Cell Polarity, Models, Biological, Protein Structure, Tertiary, rac GTP-Binding Proteins, Cell Fusion, Cytoskeletal Proteins, Phosphatidylinositol Phosphates, Multiprotein Complexes, Animals, Drosophila Proteins, Humans, Adaptor Proteins, Signal Transducing
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