descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2019 English Publisher:Elsevier BVJournal:Molecular Cell, volume 76, pages 853-855 (issn: 1097-2765,

Authors: Avinashnarayan Venkatanarayan; Shiva Malek;

doi: 10.1016/j.molcel.2019.11.020

pmid: 31951530

Partners in Crime: Clandestine Operations among RAS-RAF Accomplices in Promoting Tumorigenesis

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Abstract

In this issue of Molecular Cell, Terrell et al. (2019) characterize the interactions of RAS-RAF complexes in live cells. Using bioluminescence resonance energy transfer (BRET) technology, they show that individual RAF family members exhibit distinct binding affinities to each RAS family protein, with CRAF exhibiting high binding affinities for all RAS proteins and BRAF exhibiting increased binding affinity for KRAS.

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GENENTECH INC
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Keywords

Proto-Oncogene Proteins B-raf, Genes, ras, Carcinogenesis, ras Proteins, Humans, Crime

2 Research products, page 1 of 1

Distinct Binding Preferences Between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling by Terrell et al
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Distinct Binding Preferences between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling
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Partners in Crime: Clandestine Operations among RAS-RAF Accomplices in Promoting Tumorigenesis

Partners in Crime: Clandestine Operations among RAS-RAF Accomplices in Promoting Tumorigenesis

2 Research products, page 1 of 1

Distinct Binding Preferences Between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling by Terrell et al

Distinct Binding Preferences between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling