Gene expression profiling during the embryonic development of mouse brain using an oligonucleotide-based microarray system
Copyright policy )Gene expression profiling during the embryonic development of mouse brain using an oligonucleotide-based microarray system
We analyzed gene expression profiles in embryonic day 12, 15, 18 and postnatal day 0 mouse brains by utilizing a GeneChip microarray. Significant differential expression was observed in 1413 of 12,422 (11.4%) represented on the chip. Then, 397 genes known to be related to neural development and functions were selected and analyzed in more detail. Clustering of the differentially expressed genes in terms of gene function and their temporal expression patterns indicated an aspect of the genetic foundation that underlies cellular events. Moreover, we identified a novel gene that encodes a putative protein kinase, Ebr kinase, which is differentially expressed in the developing brain.
Mice, Inbred ICR, Reverse Transcriptase Polymerase Chain Reaction, Escherichia coli Proteins, Gene Expression Profiling, Age Factors, Brain, Embryonic Development, Gene Expression Regulation, Developmental, Membrane Proteins, Embryo, Mammalian, Antiporters, Mice, Animals, Cluster Analysis, Amino Acid Sequence, RNA, Messenger, In Situ Hybridization, Oligonucleotide Array Sequence Analysis
Mice, Inbred ICR, Reverse Transcriptase Polymerase Chain Reaction, Escherichia coli Proteins, Gene Expression Profiling, Age Factors, Brain, Embryonic Development, Gene Expression Regulation, Developmental, Membrane Proteins, Embryo, Mammalian, Antiporters, Mice, Animals, Cluster Analysis, Amino Acid Sequence, RNA, Messenger, In Situ Hybridization, Oligonucleotide Array Sequence Analysis
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).27 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!