Investigation of an NQO1 polymorphism as a possible risk and prognostic factor for chronic lymphocytic leukemia
Copyright policy )Investigation of an NQO1 polymorphism as a possible risk and prognostic factor for chronic lymphocytic leukemia
NAD(P)H:quinoneoxidoreductase 1 (NQO1) inhibits some cancers and increases p53 and apoptosis in cells. Due to an inactivating polymorphism, 10% of humans have no NQO1 activity. A case:control study suggested that chronic lymphocytic leukemia (CLL) patients may have an increased incidence of the NQO1 null genotype compared with controls. NQO1 genotype did not correlate with various CLL prognostic factors, but we observed a trend toward lower drug response in patients with the NQO1 null genotype. Inhibiting NQO1 activity decreased p53 levels and drug induced apoptosis in CLL cells. These results raise the possibility that the NQO1 polymorphism may be a risk factor for CLL and a predictor of response to chemotherapy.
- University of Manitoba Canada
Adult, Aged, 80 and over, Male, Polymorphism, Genetic, Genotype, Middle Aged, Prognosis, Leukemia, Lymphocytic, Chronic, B-Cell, Risk Factors, Case-Control Studies, NAD(P)H Dehydrogenase (Quinone), Humans, Female, Aged
Adult, Aged, 80 and over, Male, Polymorphism, Genetic, Genotype, Middle Aged, Prognosis, Leukemia, Lymphocytic, Chronic, B-Cell, Risk Factors, Case-Control Studies, NAD(P)H Dehydrogenase (Quinone), Humans, Female, Aged
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).6 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!