Cell Type-Specific Involvement of RIG-I in Antiviral Response
Copyright policy )Cell Type-Specific Involvement of RIG-I in Antiviral Response
Toll-like receptors (TLRs) play an important role in antiviral response by recognizing viral components. Recently, a RNA helicase, RIG-I, was also suggested to recognize viral double-stranded RNA. However, how these molecules contribute to viral recognition in vivo is poorly understood. We show by gene targeting that RIG-I is essential for induction of type I interferons (IFNs) after infection with RNA viruses in fibroblasts and conventional dendritic cells (DCs). RIG-I induces type I IFNs by activating IRF3 via IkappaB kinase-related kinases. In contrast, plasmacytoid DCs, which produce large amounts of IFN-alpha, use the TLR system rather than RIG-I for viral detection. Taken together, RIG-I and the TLR system exert antiviral responses in a cell type-specific manner.
- Osaka University Japan
- Kyushu University Japan
- Hyogo College of Medicine Japan
- Institute of Medical Science Japan
- Japan Science and Technology Agency Japan
Newcastle Disease, Immunology, Newcastle disease virus, Receptors, Cell Surface, Protein Serine-Threonine Kinases, DEAD-box RNA Helicases, Mice, RNA Virus Infections, Immunology and Allergy, Animals, Membrane Glycoproteins, Interferon-alpha, Dendritic Cells, Fibroblasts, I-kappa B Kinase, DNA-Binding Proteins, Infectious Diseases, Gene Targeting, Interferon Type I, DEAD Box Protein 58, Interferon Regulatory Factor-3, RNA Helicases, Signal Transduction
Newcastle Disease, Immunology, Newcastle disease virus, Receptors, Cell Surface, Protein Serine-Threonine Kinases, DEAD-box RNA Helicases, Mice, RNA Virus Infections, Immunology and Allergy, Animals, Membrane Glycoproteins, Interferon-alpha, Dendritic Cells, Fibroblasts, I-kappa B Kinase, DNA-Binding Proteins, Infectious Diseases, Gene Targeting, Interferon Type I, DEAD Box Protein 58, Interferon Regulatory Factor-3, RNA Helicases, Signal Transduction
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