Efficacy of metformin therapy in adolescent girls with androgen excess: relation to sex hormone–binding globulin and androgen receptor polymorphisms
Copyright policy )Efficacy of metformin therapy in adolescent girls with androgen excess: relation to sex hormone–binding globulin and androgen receptor polymorphisms
We studied the effects of the SHBG (TAAAA)(n) and androgen receptor gene [AR] (CAG)(n) allele length on endocrine-metabolic features and body composition (by dual-energy X-ray absorptiometry) before and after 1 year on metformin (850 mg/d) in 70 girls with polycystic ovary syndrome after precocious pubarche; allele lengths were assessed by polymerase chain reaction in both patients and in population control subjects (n = 107). Longer SHBG (TAAAA)(n) alleles (>8 repeats) were associated with more improvement of the lipid profile after 1 year on metformin, whereas longer AR (CAG)(n) alleles were related to more normalization of the androgen and lipid levels after therapy; longer alleles in both genes had an additive effect on the beneficial changes of SHBG, T, and lipids after metformin.
- University of Cambridge United Kingdom
- University of Barcelona Spain
- KU Leuven Belgium
- Katholieke Universiteit Leuven Belgium
- Hospital Sant Joan de Déu Barcelona Spain
Polymorphism, Genetic, Adolescent, Puberty, Precocious, Biomarkers, Pharmacological, Metformin, Treatment Outcome, Trinucleotide Repeats, Receptors, Androgen, Sex Hormone-Binding Globulin, Androgens, Humans, Hypoglycemic Agents, Female, Child, Hyperandrogenism, Microsatellite Repeats, Polycystic Ovary Syndrome
Polymorphism, Genetic, Adolescent, Puberty, Precocious, Biomarkers, Pharmacological, Metformin, Treatment Outcome, Trinucleotide Repeats, Receptors, Androgen, Sex Hormone-Binding Globulin, Androgens, Humans, Hypoglycemic Agents, Female, Child, Hyperandrogenism, Microsatellite Repeats, Polycystic Ovary Syndrome
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