High‐fat diet induced adiposity and insulin resistance in mice lacking the myotonic dystrophy protein kinase
Copyright policy )High‐fat diet induced adiposity and insulin resistance in mice lacking the myotonic dystrophy protein kinase
Myotonic dystrophy 1 (MD1) is caused by a CTG expansion in the 3′‐unstranslated region of the myotonic dystrophy protein kinase (DMPK) gene. MD1 patients frequently present insulin resistance and increased visceral adiposity. We examined whether DMPK deficiency is a genetic risk factor for high‐fat diet‐induced adiposity and insulin resistance using the DMPK knockout mouse model. We found that high‐fat fed DMPK knockout mice had significantly increased body weights, hypertrophic adipocytes and whole‐body insulin resistance compared with wild‐type mice. This nutrient–genome interaction should be considered by physicians given the cardiometabolic risks and sedentary lifestyle associated with MD1 patients.
Male, Mice, Knockout, Diabetes, Insulin resistance, Cell Enlargement, Protein Serine-Threonine Kinases, Weight Gain, Dietary Fats, Myotonin-Protein Kinase, Disease Models, Animal, Mice, Risk Factors, Adipocytes, Animals, Humans, Myotonic Dystrophy, Myotonic dystrophy 1, Obesity, Insulin Resistance, DMPK, Adiposity
Male, Mice, Knockout, Diabetes, Insulin resistance, Cell Enlargement, Protein Serine-Threonine Kinases, Weight Gain, Dietary Fats, Myotonin-Protein Kinase, Disease Models, Animal, Mice, Risk Factors, Adipocytes, Animals, Humans, Myotonic Dystrophy, Myotonic dystrophy 1, Obesity, Insulin Resistance, DMPK, Adiposity
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