Vascular endothelial cell senescence mediated by integrin β4 in vitro
Copyright policy )Vascular endothelial cell senescence mediated by integrin β4 in vitro
To understand whether integrin β4 is involved in vascular endothelial cell (VEC) senescence, we examined integrin β4 level changes, as well as P53 and reactive oxygen species (ROS) levels and alterations of phosphatidylcholine‐specific phospholipase C (PC‐PLC) activity before and after knocking‐down integrin β4 by small interfering RNA. We found integrin β4, P53 and ROS levels increased significantly, while Ca2+‐independent PC‐PLC activity obviously decreased during VEC senescence. On the other hand, integrin β4 down‐regulation attenuated the senescence phenotype and reversed Ca2+‐independent PC‐PLC activity, and P53 and ROS levels. The data suggested that integrin β4 might mediate VEC senescence through depressing Ca2+‐independent PC‐PLC and elevating the levels of P53 and ROS.
- Shandong Women’s University China (People's Republic of)
- Ministry of Education of the People's Republic of China China (People's Republic of)
- East Tennessee State University United States
- Institute of Genetics and Developmental Biology China (People's Republic of)
- Qilu Hospital of Shandong University China (People's Republic of)
senescence, Phosphatidylcholine-specific phospholipase C, vascular endothelial cells, 610, Down-Regulation, Integrin β4, Senescence, phosphatidylcholine-specific phospholipase C, 616, Humans, RNA, Small Interfering, Cells, Cultured, Cellular Senescence, P53, Integrin beta4, Endothelial Cells, ROS, Enzyme Activation, Type C Phospholipases, integrin β4, Calcium, Tumor Suppressor Protein p53, Reactive Oxygen Species, Vascular endothelial cells
senescence, Phosphatidylcholine-specific phospholipase C, vascular endothelial cells, 610, Down-Regulation, Integrin β4, Senescence, phosphatidylcholine-specific phospholipase C, 616, Humans, RNA, Small Interfering, Cells, Cultured, Cellular Senescence, P53, Integrin beta4, Endothelial Cells, ROS, Enzyme Activation, Type C Phospholipases, integrin β4, Calcium, Tumor Suppressor Protein p53, Reactive Oxygen Species, Vascular endothelial cells
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