Correlation of UGT1A128 and 6 polymorphisms with irinotecan-induced neutropenia in Thai colorectal cancer patients
Copyright policy )Correlation of UGT1A128 and 6 polymorphisms with irinotecan-induced neutropenia in Thai colorectal cancer patients
UDP-glucuronosyltransferase1A1 (UGT1A1) polymorphisms have been related with irinotecan toxicity. The purpose of this study was to determine the associations between UGT1A1(*)28 and (*)6 polymorphisms and irinotecan toxicity in Thai patients with metastatic colorectal cancer. 44 metastatic colorectal cancer patients received irinotecan-based chemotherapy. Hematologic toxicities were determined in the first and second cycles of treatment. The genotypes of UGT1A1(*)28 and (*)6 were analyzed by pyrosequencing technique. The frequencies of genetic testing for UGT1A1(*)28 and (*)6 polymorphisms were 22.8% (TA6/TA7; 20.5%, TA7/TA7; 2.3%) and 15.9% (GA), respectively. No patients had the homozygous UGT1A1(*)6 (AA). Neither UGT1A1(*)28 nor UGT1A1(*)6 polymorphisms were significantly associated with severe hematologic toxicities. However, analysis of UGT1A1(*)28 and (*)6 in combination revealed an association with severe neutropenia in the first and second cycles (P = 0.044, P = 0.017, respectively). Both UGT1A1(*)28 and (*)6 polymorphisms may have an increased risk of irinotecan-induced neutropenia in Thai colorectal cancer patients.
- Mahidol University Thailand
- Ramathibodi Hospital Thailand
Adult, Aged, 80 and over, Male, Risk, Neutropenia, Polymorphism, Genetic, Genotype, Middle Aged, Irinotecan, Thailand, Asian People, Humans, Camptothecin, Female, Genetic Predisposition to Disease, Glucuronosyltransferase, Colorectal Neoplasms, Aged
Adult, Aged, 80 and over, Male, Risk, Neutropenia, Polymorphism, Genetic, Genotype, Middle Aged, Irinotecan, Thailand, Asian People, Humans, Camptothecin, Female, Genetic Predisposition to Disease, Glucuronosyltransferase, Colorectal Neoplasms, Aged
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