Leading Wnt down a PCP Path: Cthrc1 Acts as a Coreceptor in the Wnt-PCP Pathway
pmid: 18606135
Leading Wnt down a PCP Path: Cthrc1 Acts as a Coreceptor in the Wnt-PCP Pathway
Wnt signaling regulates many aspects of development through canonical and PCP signaling pathways. A paper by Yamamoto et al. in this issue of Developmental Cell identifies collagen triple helix repeat containing 1 as a Wnt-binding cofactor that specifically activates the Wnt-PCP pathway.
- National Institutes of Health United States
- National Institute of Health Pakistan
- National Institute on Deafness and Other Communication Disorders United States
Mice, Knockout, Hair Cells, Auditory, Inner, Cell Polarity, Receptor Protein-Tyrosine Kinases, Embryo, Mammalian, Receptor Tyrosine Kinase-like Orphan Receptors, Frizzled Receptors, Wnt Proteins, Mice, Mutation, Animals, Developmental Biology, Glycoproteins, Signal Transduction
Mice, Knockout, Hair Cells, Auditory, Inner, Cell Polarity, Receptor Protein-Tyrosine Kinases, Embryo, Mammalian, Receptor Tyrosine Kinase-like Orphan Receptors, Frizzled Receptors, Wnt Proteins, Mice, Mutation, Animals, Developmental Biology, Glycoproteins, Signal Transduction
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