SIRT6 transcriptionally regulates fatty acid transport by suppressing PPARγ
Copyright policy )SIRT6 transcriptionally regulates fatty acid transport by suppressing PPARγ
Pathological lipid accumulation is often associated with enhanced uptake of free fatty acids via specific transporters in cardiomyocytes. Here, we identify SIRT6 as a critical transcriptional regulator of fatty acid transporters in cardiomyocytes. We find that SIRT6 deficiency enhances the expression of fatty acid transporters, leading to enhanced fatty acid uptake and lipid accumulation. Interestingly, the haploinsufficiency of SIRT6 is sufficient to induce the expression of fatty acid transporters and cause lipid accumulation in murine hearts. Mechanistically, SIRT6 depletion enhances the occupancy of the transcription factor PPARγ on the promoters of critical fatty acid transporters without modulating the acetylation of histone 3 at Lys 9 and Lys 56. Notably, the binding of SIRT6 to the DNA-binding domain of PPARγ is critical for regulating the expression of fatty acid transporters in cardiomyocytes. Our data suggest exploiting SIRT6 as a potential therapeutic target for protecting the heart from metabolic diseases.
- Indian Council of Agricultural Research India
- Indian Institute of Science Bangalore India
- Harvard Medical School United States
- Sri Jayadeva Institute of Cardiovascular Sciences and Research India
- Harvard University United States
Adult, Heart Failure, Male, Transcription, Genetic, Diabetic Cardiomyopathies, Fatty Acids, Membrane Transport Proteins, Biological Transport, Article, Mice, Inbred C57BL, PPAR gamma, Disease Models, Animal, Mice, HEK293 Cells, Protein Domains, Animals, Humans, Sirtuins, Female, Myocytes, Cardiac, Promoter Regions, Genetic
Adult, Heart Failure, Male, Transcription, Genetic, Diabetic Cardiomyopathies, Fatty Acids, Membrane Transport Proteins, Biological Transport, Article, Mice, Inbred C57BL, PPAR gamma, Disease Models, Animal, Mice, HEK293 Cells, Protein Domains, Animals, Humans, Sirtuins, Female, Myocytes, Cardiac, Promoter Regions, Genetic
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