Alzheimer's Disease Neurons Fail the Acid Test
Copyright policy )Alzheimer's Disease Neurons Fail the Acid Test
Mutations in the presenilin genes are the most common cause of familial forms of Alzheimer's disease. Although it is well known for its role in the generation of amyloid peptide, Lee et al. (2010) now report that presenilin 1 deficiency also impacts maturation of the lysosomal proton pump, affecting autophagocytosis and protein turnover.
- KU Leuven Belgium
- Katholieke Universiteit Leuven Belgium
- Centre For Human Genetics India
Biochemistry & Molecular Biology, Science & Technology, Biochemistry, Genetics and Molecular Biology(all), 31 Biological sciences, AUTOPHAGY, Cell Biology, 32 Biomedical and clinical sciences, 06 Biological Sciences, Life Sciences & Biomedicine, 11 Medical and Health Sciences, Developmental Biology
Biochemistry & Molecular Biology, Science & Technology, Biochemistry, Genetics and Molecular Biology(all), 31 Biological sciences, AUTOPHAGY, Cell Biology, 32 Biomedical and clinical sciences, 06 Biological Sciences, Life Sciences & Biomedicine, 11 Medical and Health Sciences, Developmental Biology
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