Bone Formation: The Nuclear Matrix Reloaded
Copyright policy )Bone Formation: The Nuclear Matrix Reloaded
In this issue of Cell, Grosschedl and colleagues (Dobreva et al., 2006) report that the nuclear matrix protein Satb2 represses Hoxa2 expression and acts with other regulatory proteins to promote osteoblast differentiation. This work suggests a molecular mechanism that enables the integration of patterning and differentiation during bone formation.
- University of Kansas Medical Center United States
- Stowers Institute for Medical Research United States
- University of Kansas United States
Homeodomain Proteins, Osteoblasts, Biochemistry, Genetics and Molecular Biology(all), Gene Expression Regulation, Developmental, Cell Differentiation, Mesenchymal Stem Cells, Matrix Attachment Region Binding Proteins, Bone and Bones, Neural Crest, Osteogenesis, Animals, Humans, Nuclear Matrix, Body Patterning, Transcription Factors
Homeodomain Proteins, Osteoblasts, Biochemistry, Genetics and Molecular Biology(all), Gene Expression Regulation, Developmental, Cell Differentiation, Mesenchymal Stem Cells, Matrix Attachment Region Binding Proteins, Bone and Bones, Neural Crest, Osteogenesis, Animals, Humans, Nuclear Matrix, Body Patterning, Transcription Factors
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