descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2006 English Publisher:Elsevier BVJournal:Cell, volume 124, pages 15-17 (issn: 0092-8674,

Authors: Hayward, Richard D.; Koronakis, Vassilis;

doi: 10.1016/j.cell.2005.12.024

pmid: 16413475

Pathogens reWritE Rho's Rules

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Abstract

Many bacterial pathogens use a specialized "type III" secretion system to deliver virulence effector proteins into host mammalian cells. In this issue of Cell, Alto et al. (2006) describe a new family of effectors that share a WxxxE sequence motif. These effectors directly stimulate host signaling pathways by mimicking activated Ras-like cellular GTPases.

Related Organizations

University of Cambridge
United Kingdom

Keywords

Bacteria, Bacterial Proteins, Virulence, Biochemistry, Genetics and Molecular Biology(all), Amino Acid Motifs, Molecular Mimicry, ras Proteins, Humans, Signal Transduction

8 Research products, page 1 of 1

Prevention of the cytopathic effect induced by Clostridium difficile Toxin B by active Rac1
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Structural insights into host GTPase isoform selection by a family of bacterial GEF mimics
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Probing the Cellular Effects of Bacterial Effector Proteins with the Yersinia Toolbox
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Bacterial Guanine Nucleotide Exchange Factors SopE-Like and WxxxE Effectors
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Molecular Mechanisms of Host Cytoskeletal Rearrangements by Shigella Invasins
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Funktionelle Analyse von bakteriellen W-xxx-E Rho GTPasen GEF Mimetika mittels Typ 3 Sekretionssystems von Yersinia enterocolitica
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Identification of a Bacterial Type III Effector Family with G Protein Mimicry Functions
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IpgB1 and IpgB2, two homologous effectors secreted via the Mxi-Spa type III secretion apparatus, cooperate to mediate polarized cell invasion and inflammatory potential of Shigella flexenri
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Pathogens reWritE Rho's Rules

Pathogens reWritE Rho's Rules

8 Research products, page 1 of 1

Prevention of the cytopathic effect induced by Clostridium difficile Toxin B by active Rac1

Structural insights into host GTPase isoform selection by a family of bacterial GEF mimics

Probing the Cellular Effects of Bacterial Effector Proteins with the Yersinia Toolbox

Bacterial Guanine Nucleotide Exchange Factors SopE-Like and WxxxE Effectors

Molecular Mechanisms of Host Cytoskeletal Rearrangements by Shigella Invasins

Funktionelle Analyse von bakteriellen W-xxx-E Rho GTPasen GEF Mimetika mittels Typ 3 Sekretionssystems von Yersinia enterocolitica

Identification of a Bacterial Type III Effector Family with G Protein Mimicry Functions

IpgB1 and IpgB2, two homologous effectors secreted via the Mxi-Spa type III secretion apparatus, cooperate to mediate polarized cell invasion and inflammatory potential of Shigella flexenri