Human ovarian cancer cell morphology, motility, and proliferation are differentially influenced by autocrine TGFβ superfamily signalling
Copyright policy )Human ovarian cancer cell morphology, motility, and proliferation are differentially influenced by autocrine TGFβ superfamily signalling
TGFβ superfamily signalling participates in normal and pathophysiologic cellular processes. Despite several reports demonstrating active TGFβ superfamily signalling pathways in OvCa cell lines and primary cultures, few studies examine their functional outcome. Herein we show that primary human ovarian cancer cells possess intact autocrine BMP, TGFβ and activin signalling. Blocking autocrine signalling resulted in differential cellular responses affecting cellular morphology, motility and proliferation. Additionally, BMP4-induced alterations in morphology and motility are dependent on Smad signalling. These results suggest that a balance between BMP and TGFβ/activin signalling may be altered to favour BMP signalling during ovarian cancer metastatic progression.
- Dalhousie University Canada
- University of Manitoba Canada
Inhibitor of Differentiation Protein 1, Ovarian Neoplasms, Reverse Transcriptase Polymerase Chain Reaction, Blotting, Western, Molecular Sequence Data, Gene Expression, Smad Proteins, Recombinant Proteins, Activins, Cell Line, Autocrine Communication, Cell Movement, Bone Morphogenetic Proteins, Humans, Female, RNA Interference, Snail Family Transcription Factors, Cell Shape, Cell Proliferation, Transcription Factors
Inhibitor of Differentiation Protein 1, Ovarian Neoplasms, Reverse Transcriptase Polymerase Chain Reaction, Blotting, Western, Molecular Sequence Data, Gene Expression, Smad Proteins, Recombinant Proteins, Activins, Cell Line, Autocrine Communication, Cell Movement, Bone Morphogenetic Proteins, Humans, Female, RNA Interference, Snail Family Transcription Factors, Cell Shape, Cell Proliferation, Transcription Factors
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