Genetic polymorphisms in CYP1B1, GSTA1, NQO1 and NAT2 and the risk of lung cancer
Copyright policy )Genetic polymorphisms in CYP1B1, GSTA1, NQO1 and NAT2 and the risk of lung cancer
In a population-based case-cohort study, we have investigated the occurrence of lung cancer in relation to polymorphisms in the phase I gene cytochrome P450 1B1 and in the phase II genes glutathione S-transferase A1, NAD(P)H quinone oxidoreductase and N-acetyltransferase 2 (NAT2). Among 54,220 cohort members, 265 lung cancer cases were identified and a sub-cohort comprising 272 individuals was used for comparison. No overall associations were found between the polymorphisms and risk of lung cancer. The NAT2 fast acetylator genotype seemed to be protective against lung cancer in light smokers (20 cigarettes/day).
- Danish Ramazzini Center Denmark
- Aarhus University Denmark
- Aalborg Hospital Denmark
- Danish Cancer Society Denmark
- Aarhus University Hospital Denmark
Lung Neoplasms, Polymorphism, Genetic, Arylamine N-Acetyltransferase, Smoking, Middle Aged, Cohort Studies, Cytochrome P-450 Enzyme System, Risk Factors, Carcinoma, Non-Small-Cell Lung, Case-Control Studies, Cytochrome P-450 CYP1B1, Carcinoma, Squamous Cell, NAD(P)H Dehydrogenase (Quinone), Humans, Aryl Hydrocarbon Hydroxylases, Prospective Studies, Carcinoma, Small Cell, Carrier Proteins, Aged, Glutathione Transferase
Lung Neoplasms, Polymorphism, Genetic, Arylamine N-Acetyltransferase, Smoking, Middle Aged, Cohort Studies, Cytochrome P-450 Enzyme System, Risk Factors, Carcinoma, Non-Small-Cell Lung, Case-Control Studies, Cytochrome P-450 CYP1B1, Carcinoma, Squamous Cell, NAD(P)H Dehydrogenase (Quinone), Humans, Aryl Hydrocarbon Hydroxylases, Prospective Studies, Carcinoma, Small Cell, Carrier Proteins, Aged, Glutathione Transferase
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