Expression of prokineticin receptors in mouse cultured astrocytes and involvement in cell proliferation
Copyright policy )Expression of prokineticin receptors in mouse cultured astrocytes and involvement in cell proliferation
Effects of prokineticins (PKs), a novel family of bioactive peptides with a mitogenic action to endothelial cells of the endocrine gland and testis, on astrocytic functions were examined. Mouse cultured astrocytes expressed PK-R1 type PK receptors, while there was little expression of the PK-R2 type. PKs caused increases in astrocytic cytosolic Ca2+ levels and BrdU incorporation. Increases in Ca2+ levels by PK-2 were diminished by U73122 (a phospholipase C inhibitor). PK-induced BrdU incorporation was inhibited by U73122, GF109203 (a protein kinase C inhibitor) and PD98059 (a MEK/ERK inhibitor). These results indicate that PK receptors are expressed in astrocytes and regulate astrocytic proliferation.
- Osaka University Japan
Flavonoids, Dose-Response Relationship, Drug, Neuropeptides, Gene Expression, Embryo, Mammalian, Pyrrolidinones, Receptors, G-Protein-Coupled, Gastrointestinal Hormones, Mice, Animals, Newborn, Bromodeoxyuridine, Astrocytes, Cerebellum, Animals, Calcium, Vascular Endothelial Growth Factor, Endocrine-Gland-Derived, Enzyme Inhibitors, Estrenes, Cells, Cultured, Cell Proliferation
Flavonoids, Dose-Response Relationship, Drug, Neuropeptides, Gene Expression, Embryo, Mammalian, Pyrrolidinones, Receptors, G-Protein-Coupled, Gastrointestinal Hormones, Mice, Animals, Newborn, Bromodeoxyuridine, Astrocytes, Cerebellum, Animals, Calcium, Vascular Endothelial Growth Factor, Endocrine-Gland-Derived, Enzyme Inhibitors, Estrenes, Cells, Cultured, Cell Proliferation
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