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A novel chemotype of kinase inhibitors: Discovery of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Jan 2010Publisher:Elsevier BVJournal:Bioorganic & Medicinal Chemistry Letters, volume 20, pages 153-156 (issn: 0960-894X,

Authors: Tiansheng, Wang; Mark W, Ledeboer; John P, Duffy; Francesco G, Salituro; Albert C, Pierce; Harmon J, Zuccola; Eric, Block; +3 Authors

doi: 10.1016/j.bmcl.2009.11.021 , 10.1002/chin.201021172

pmid: 19945871

A novel chemotype of kinase inhibitors: Discovery of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors

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Abstract

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Related Organizations

Vertex Pharmaceuticals (United States)
United States

Keywords

Binding Sites, Indoles, Janus Kinase 2, Crystallography, X-Ray, Cell Line, Structure-Activity Relationship, Purines, Benzaldehydes, Drug Discovery, Humans, Protein Kinase Inhibitors

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BindingDB Entry 50031006: A novel chemotype of kinase inhibitors: Discovery of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors.
2010IsSourceOf
Tyrosine-protein kinase JAK2
2017IsRelatedTo
3KCK
2009IsSupplementTo
3KCK
2009IsRelatedTo

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	46
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%

A novel chemotype of kinase inhibitors: Discovery of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors

A novel chemotype of kinase inhibitors: Discovery of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors

4 Research products, page 1 of 1

BindingDB Entry 50031006: A novel chemotype of kinase inhibitors: Discovery of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors.

Tyrosine-protein kinase JAK2

3KCK

3KCK