Rudiment incisors survive and erupt as supernumerary teeth as a result of USAG-1 abrogation
Copyright policy )Rudiment incisors survive and erupt as supernumerary teeth as a result of USAG-1 abrogation
The term "supernumerary teeth" describes production of more than the normal number of teeth in the primary or permanent dentitions. Their aetiology is not understood. Uterine sensitization associated gene-1 (USAG-1) is a BMP antagonist that plays important roles in the local regulation of BMP signaling by binding and neutralizing BMP activities, and also serves as a modulator of Wnt signaling. We report here that USAG-1 deficient mice have supernumerary teeth. The supernumerary maxillary incisor appears to form as a result of the successive development of the rudimentary upper incisor tooth. We confirmed that the USAG-1 expression is localized to the epithelium and mesenchyme of the rudimentary maxillary incisor tooth organ formation. USAG-1 abrogation rescued apoptotic elimination of odontogenic mesenchymal cells. Based upon these results, we conclude that USAG-1 controls the number of teeth in the maxillary incisor region by regulating apoptosis.
- Kyoto University Japan
- University of Southern California United States
- University of Tsukuba Japan
- University of California System United States
- Japan Science and Technology Agency Japan
Mice, Knockout, Tooth Germ, Apoptosis, Mesenchymal Stem Cells, Incisor, Mice, Inbred C57BL, Mice, Phenotype, Gene Expression Regulation, Tooth, Supernumerary, Bone Morphogenetic Proteins, Animals, Odontogenesis, Adaptor Proteins, Signal Transducing, Body Patterning
Mice, Knockout, Tooth Germ, Apoptosis, Mesenchymal Stem Cells, Incisor, Mice, Inbred C57BL, Mice, Phenotype, Gene Expression Regulation, Tooth, Supernumerary, Bone Morphogenetic Proteins, Animals, Odontogenesis, Adaptor Proteins, Signal Transducing, Body Patterning
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