Soluble HLA-G generated by proteolytic shedding inhibits NK-mediated cell lysis
Copyright policy )Soluble HLA-G generated by proteolytic shedding inhibits NK-mediated cell lysis
In contrast to the classical HLA class Ia molecules, the nonclassical HLA-G primary transcript is alternatively spliced to generate several mRNAs that encode four membrane-bound and three soluble isoforms. This study demonstrated that the soluble form of HLA-G can also be generated by metalloproteinase-dependent shedding at post-translational level. These soluble HLA-G1 molecules generated by the cleavage of membrane-bound HLA-G1 associate with beta2-microglobulin and contain bound peptides that are stable at physiological conditions. This report further showed that the soluble HLA-G1 is able to protect HLA class I-negative K562 cells from NK lysis, suggesting that soluble HLA-G could act as an immunoregulator in NK cell recognition and possibly in other immune responses.
- Korea University Korea (Republic of)
HLA-G Antigens, Time Factors, Blotting, Western, Cell Membrane, Histocompatibility Antigens Class I, Temperature, Precipitin Tests, Killer Cells, Natural, Alternative Splicing, HLA Antigens, Metalloproteases, Humans, Protein Isoforms, Biotinylation, Electrophoresis, Polyacrylamide Gel, RNA, Messenger, K562 Cells, Peptides, beta 2-Microglobulin, Protein Processing, Post-Translational
HLA-G Antigens, Time Factors, Blotting, Western, Cell Membrane, Histocompatibility Antigens Class I, Temperature, Precipitin Tests, Killer Cells, Natural, Alternative Splicing, HLA Antigens, Metalloproteases, Humans, Protein Isoforms, Biotinylation, Electrophoresis, Polyacrylamide Gel, RNA, Messenger, K562 Cells, Peptides, beta 2-Microglobulin, Protein Processing, Post-Translational
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).153 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!