A conserved function for Inp2 in peroxisome inheritance
Copyright policy )A conserved function for Inp2 in peroxisome inheritance
In budding yeast Saccharomyces cerevisiae, the peroxisomal protein Inp2 is required for inheritance of peroxisomes to the bud, by connecting the organelles to the motor protein Myo2 and the actin cytoskeleton. Recent data suggested that the function of Inp2 may not be conserved in other yeast species. Using in silico analyses we have identified a weakly conserved Inp2-related protein in 18 species of budding yeast and analyzed the role of the identified protein in the methylotrophic yeast Hansenula polymorpha in peroxisome inheritance. Our data show that H. polymorpha Inp2 locates to peroxisomes, interacts with Myo2, and is essential for peroxisome inheritance.
- University of Groningen Netherlands
GENES, Saccharomyces cerevisiae Proteins, Organelle inheritance, EFFICIENT, Receptors, Cytoplasmic and Nuclear, Saccharomyces cerevisiae, METABOLISM, Peroxisome, Pichia, SACCHAROMYCES-CEREVISIAE, Fungal Proteins, Protein-protein interaction, Two-Hybrid System Techniques, Peroxisomes, Budding yeast, YARROWIA-LIPOLYTICA, Molecular Biology, Cytoskeleton, MEMBRANE-PROTEINS, PROLIFERATION, Membrane Proteins, Cell Biology, Actins, Protein–protein interaction, ALIGNMENT, SIMILARITY, HANSENULA-POLYMORPHA
GENES, Saccharomyces cerevisiae Proteins, Organelle inheritance, EFFICIENT, Receptors, Cytoplasmic and Nuclear, Saccharomyces cerevisiae, METABOLISM, Peroxisome, Pichia, SACCHAROMYCES-CEREVISIAE, Fungal Proteins, Protein-protein interaction, Two-Hybrid System Techniques, Peroxisomes, Budding yeast, YARROWIA-LIPOLYTICA, Molecular Biology, Cytoskeleton, MEMBRANE-PROTEINS, PROLIFERATION, Membrane Proteins, Cell Biology, Actins, Protein–protein interaction, ALIGNMENT, SIMILARITY, HANSENULA-POLYMORPHA
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