The importance of accessory protein variants in the pathogenicity of SARS-CoV-2
Copyright policy )The importance of accessory protein variants in the pathogenicity of SARS-CoV-2
The coronavirus disease 2019 (COVID-19) is caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS- CoV-2) with an estimated fatality rate of less than 1%. The SARS-CoV-2 accessory proteins ORF3a, ORF6, ORF7a, ORF7b, ORF8, and ORF10 possess putative functions to manipulate host immune mechanisms. These involve interferons, which appear as a consensus function, immune signaling receptor NLRP3 (NLR family pyrin domain-containing 3) inflammasome, and inflammatory cytokines such as interleukin 1β (IL-1β) and are critical in COVID-19 pathology. Outspread variations of each of the six accessory proteins were observed across six continents of all complete SARS-CoV-2 proteomes based on the data reported before November 2020. A decreasing order of percentage of unique variations in the accessory proteins was determined as ORF3a > ORF8 > ORF7a > ORF6 > ORF10 > ORF7b across all continents. The highest and lowest unique variations of ORF3a were observed in South America and Oceania, respectively. These findings suggest that the wide variations in accessory proteins seem to affect the pathogenicity of SARS-CoV-2.
- Universal Scientific Education and Research Network Iran (Islamic Republic of)
- University of Valencia Spain
- Mayo Clinic United States
- Monterrey Institute of Technology and Higher Education Mexico
- University of Padua Italy
570, 572, SARS-CoV-2, ORF3a, 610, ORF7b, COVID-19, Genetic Variation, ORF7a, ORF8, ORF6, Article, Viroporin Proteins, Viral Proteins, ORF10, Medicine and Health Sciences, Pathogenicity, Humans, Phylogeny
570, 572, SARS-CoV-2, ORF3a, 610, ORF7b, COVID-19, Genetic Variation, ORF7a, ORF8, ORF6, Article, Viroporin Proteins, Viral Proteins, ORF10, Medicine and Health Sciences, Pathogenicity, Humans, Phylogeny
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