Genetic mapping in the region of the mouse X-inactivation center
pmid: 1974879
Genetic mapping in the region of the mouse X-inactivation center
The mouse X-inactivation center lies just distal to the T16H breakpoint. Utilizing pedigree analysis of backcross progeny from a Mus domesticus/Mus spretus interspecific cross, we have mapped a number of genetic loci, gene probes, microclones, and EagI linking clones distal to the T16H breakpoint. The genetic analysis provides a detailed genetic map in the vicinity of the mouse X-inactivation center. Comparative mapping data from the human X chromosome indicate that the most probable location of the mouse X-inactivation center is distal to Ccg-1 and in the region of the Pgk-1 locus. We report the assignment of two new loci, EM13 and DXSmh44, to the Ccg-1/Pgk-1 interval.
- Imperial College London United Kingdom
- Massachusetts Institute of Technology United States
- Center for Clinical Research (United States) United States
Muridae, Blotting, Southern, X Chromosome, Dosage Compensation, Genetic, Animals, Chromosome Mapping, Crosses, Genetic, Polymorphism, Restriction Fragment Length
Muridae, Blotting, Southern, X Chromosome, Dosage Compensation, Genetic, Animals, Chromosome Mapping, Crosses, Genetic, Polymorphism, Restriction Fragment Length
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