MicroRNA-30c targets cytoskeleton genes involved in breast cancer cell invasion
Copyright policy )MicroRNA-30c targets cytoskeleton genes involved in breast cancer cell invasion
Metastasis remains a significant challenge in treating cancer. A better understanding of the molecular mechanisms underlying metastasis is needed to develop more effective treatments. Here we show that human breast tumor biomarker miR-30c regulates invasion by targeting the cytoskeleton network genes encoding Twinfilin 1 (TWF1) and Vimentin (VIM). Both VIM and TWF1 have been shown to regulate epithelial-to-mesenchymal transition (EMT). Similar to TWF1, VIM also regulates F-actin formation, a key component of cellular transition to a more invasive mesenchymal phenotype. To further characterize the role of the TWF1 pathway in breast cancer, we found that IL-11 is an important target of TWF1 that regulates breast cancer cell invasion and STAT3 phosphorylation. The miR-30c-VIM/TWF1 signaling cascade is also associated with clinical outcome in breast cancer patients.
- University of North Carolina at Chapel Hill United States
- Stanford University School of Medicine United States
- University of Chicago United States
- Stanford University United States
- UNC Lineberger Comprehensive Cancer Center United States
Epithelial-Mesenchymal Transition, Base Sequence, Microfilament Proteins, Molecular Sequence Data, Breast Neoplasms, Protein-Tyrosine Kinases, Interleukin-11, Xenograft Model Antitumor Assays, Gene Expression Regulation, Neoplastic, Mice, MicroRNAs, Cell Line, Tumor, Animals, Humans, Vimentin, Female, Cytoskeleton
Epithelial-Mesenchymal Transition, Base Sequence, Microfilament Proteins, Molecular Sequence Data, Breast Neoplasms, Protein-Tyrosine Kinases, Interleukin-11, Xenograft Model Antitumor Assays, Gene Expression Regulation, Neoplastic, Mice, MicroRNAs, Cell Line, Tumor, Animals, Humans, Vimentin, Female, Cytoskeleton
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