Physical and genetic localization of quinonoid dihydropteridine reductase gene (QDPR) on short arm of chromosome 4
Copyright policy )Physical and genetic localization of quinonoid dihydropteridine reductase gene (QDPR) on short arm of chromosome 4
A portion of a cDNA clone corresponding to the 3' end of the human quinonoid dihydropteridine reductase (QDPR) mRNA was used as a probe to physically map the QDPR gene by analysis of somatic cell hybrid lines. The provisional assignment of QDPR to chromosome 4, based on expression of the human enzyme in hybrids, was confirmed. The gene was further regionally localized on the short arm to 4p16.1----4p15.1. This physical localization places QDPR in the same area of the genome that contains the defect causing Huntington's disease (HD). The QDPR probe revealed a restriction fragment length polymorphism with the enzyme BanII, permitting determination of its genetic proximity to D4S10, an anonymous DNA marker tightly linked to HD. QDPR is only loosely linked to D4S10, excluding any primary role for the gene in HD.
- National Institute of Health Pakistan
- Baylor College of Medicine United States
- Massachusetts General Hospital United States
- National Institutes of Health United States
- Harvard University United States
Genetic Markers, Male, Chromosome Mapping, DNA, Hybrid Cells, Pedigree, Huntington Disease, Genes, Cricetinae, Animals, Humans, Female, Chromosomes, Human, Pair 4, Oxidoreductases, Polymorphism, Restriction Fragment Length
Genetic Markers, Male, Chromosome Mapping, DNA, Hybrid Cells, Pedigree, Huntington Disease, Genes, Cricetinae, Animals, Humans, Female, Chromosomes, Human, Pair 4, Oxidoreductases, Polymorphism, Restriction Fragment Length
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).19 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!