Mapping of the interleukin 5 receptor gene to human Chromosome 3 p25?p26 and to mouse Chromosome 6 close to the Raf-1 locus with polymorphic tandem repeat sequences
Copyright policy )Mapping of the interleukin 5 receptor gene to human Chromosome 3 p25?p26 and to mouse Chromosome 6 close to the Raf-1 locus with polymorphic tandem repeat sequences
Simple-sequence tandem repeat sequences in the 3' UTR of interleukin 5 (IL5)-receptor gene of human and mouse are polymorphic in their length among humans and different strains of mice. In 20 different human Epstein-Barr virus (EBV)-transformed cell lines, six alleles of IL5R could be distinguished. In the mouse, three different alleles are found. With the human-specific IL5R tandem repeat marker in human-rodent somatic cell hybrids, the IL5R gene was mapped to human Chromosome (Chr) 3 p25-p26. With the mouse-specific IL5R tandem repeat sequence in recombinant inbred strains of mice, the Il5r gene was mapped to the distal part of mouse Chr 6 close to the Raf-1 locus.
- University of Colorado Anschutz Medical Campus United States
- Stanford University United States
- University of Colorado Cancer Center United States
Genetic Markers, Mice, Inbred C3H, Base Sequence, Molecular Sequence Data, DNA, Recombinant, Chromosome Mapping, Receptors, Interleukin, Hybrid Cells, Receptors, Interleukin-5, Mice, Inbred C57BL, Mice, Mice, Inbred DBA, Proto-Oncogenes, Animals, Humans, Chromosomes, Human, Pair 3, Interleukin-4, Receptors, Immunologic, Conserved Sequence, Polymorphism, Restriction Fragment Length
Genetic Markers, Mice, Inbred C3H, Base Sequence, Molecular Sequence Data, DNA, Recombinant, Chromosome Mapping, Receptors, Interleukin, Hybrid Cells, Receptors, Interleukin-5, Mice, Inbred C57BL, Mice, Mice, Inbred DBA, Proto-Oncogenes, Animals, Humans, Chromosomes, Human, Pair 3, Interleukin-4, Receptors, Immunologic, Conserved Sequence, Polymorphism, Restriction Fragment Length
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