Structure of the CAP-DNA Complex at 2.5 Å Resolution: A Complete Picture of the Protein-DNA Interface
Copyright policy )Structure of the CAP-DNA Complex at 2.5 Å Resolution: A Complete Picture of the Protein-DNA Interface
The crystallographic structure of the CAP-DNA complex at 3.0 A resolution has been reported previously. For technical reasons, the reported structure had been determined using a gapped DNA molecule lacking two phosphates important for CAP-DNA interaction. In this work, we report the crystallographic structure of the CAP-DNA complex at 2.5 A resolution using a DNA molecule having all phosphates important for CAP-DNA interaction. The present resolution permits unambiguous identification of amino acid-base and amino acid-phosphate hydrogen bonded contacts in the CAP-DNA complex. In addition, the present resolution permits accurate definition of the kinked DNA conformation in the CAP-DNA complex.
- Rutgers, The State University of New Jersey United States
Models, Molecular, Base Composition, Cyclic AMP Receptor Protein, Base Sequence, Protein Conformation, Molecular Sequence Data, Nucleic Acid Conformation, DNA, Crystallography, X-Ray, Phosphates
Models, Molecular, Base Composition, Cyclic AMP Receptor Protein, Base Sequence, Protein Conformation, Molecular Sequence Data, Nucleic Acid Conformation, DNA, Crystallography, X-Ray, Phosphates
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