Detection and Isolation of a Novel Human Gene Located on Xp11.2–p11.4 That Escapes X-Inactivation Using a Two-Dimensional DNA Mapping Method
Copyright policy )Detection and Isolation of a Novel Human Gene Located on Xp11.2–p11.4 That Escapes X-Inactivation Using a Two-Dimensional DNA Mapping Method
Using a two-dimensional DNA mapping method, we detected four NotI restriction sites that escape chromosome X-specific methylation in humans. Two genes corresponding to two of these sites that lie in the region of Xp11.2-p11.4 were cloned and their properties studied. One of the genes matched a known gene, but the other, termed EXLM1, is novel and is predominantly expressed in cultured lymphocytes and skeletal muscle.
- University of Tokyo Japan
- Osaka University Japan
- National Institute of Genetics Japan
DNA, Complementary, Mediator Complex, X Chromosome, Base Sequence, Transcription, Genetic, Molecular Sequence Data, Restriction Mapping, Sequence Analysis, DNA, DNA Methylation, Blotting, Southern, Organ Specificity, Dosage Compensation, Genetic, Trans-Activators, Animals, Humans, Electrophoresis, Gel, Two-Dimensional, Amino Acid Sequence, Cloning, Molecular, Deoxyribonucleases, Type II Site-Specific, Cell Line, Transformed
DNA, Complementary, Mediator Complex, X Chromosome, Base Sequence, Transcription, Genetic, Molecular Sequence Data, Restriction Mapping, Sequence Analysis, DNA, DNA Methylation, Blotting, Southern, Organ Specificity, Dosage Compensation, Genetic, Trans-Activators, Animals, Humans, Electrophoresis, Gel, Two-Dimensional, Amino Acid Sequence, Cloning, Molecular, Deoxyribonucleases, Type II Site-Specific, Cell Line, Transformed
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