Comparative Mapping of the Actin-Binding Protein 280 Genes in Human and Mouse
Copyright policy )Comparative Mapping of the Actin-Binding Protein 280 Genes in Human and Mouse
Two genes encode actin-binding protein 280 isoforms. ABP-280 or filamin (FLN1) is present in the cytoskeleton of many cell types, whereas expression of FLN2 is limited to skeletal muscle and heart. FLN1 maps to human chromosome Xq28, and, by physical mapping in YAC clones, we have mapped the homologous murine locus (Fln1) to mouse chromosome X, in a region of syntenic homology with human chromosome X. We mapped FLN2 to human chromosome 7q32-q35 by analysis of somatic cell hybrids containing portions of chromosome 7, and, by using a mapping panel from an interspecific murine cross, we mapped the corresponding murine locus (Fln2) to murine chromosome 6 in a region homologous to human chromosome 7.
- Baylor College of Medicine United States
- University of Bari Aldo Moro Italy
- Vita-Salute San Raffaele University Italy
Mice, Inbred C3H, X Chromosome, Base Sequence, Genetic Linkage, Filamins, Microfilament Proteins, Molecular Sequence Data, Chromosome Mapping, Hybrid Cells, Polymerase Chain Reaction, Mice, Inbred C57BL, Muridae, Mice, Contractile Proteins, Cricetinae, Animals, Humans, Chromosomes, Human, Pair 7, Crosses, Genetic, DNA Primers
Mice, Inbred C3H, X Chromosome, Base Sequence, Genetic Linkage, Filamins, Microfilament Proteins, Molecular Sequence Data, Chromosome Mapping, Hybrid Cells, Polymerase Chain Reaction, Mice, Inbred C57BL, Muridae, Mice, Contractile Proteins, Cricetinae, Animals, Humans, Chromosomes, Human, Pair 7, Crosses, Genetic, DNA Primers
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).18 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!