BIFUNCTIONAL EFFECTS OF HEPARIN‐BINDING PROTEIN HBp17 ON DNA SYNTHESIS IN CELLS
Copyright policy )BIFUNCTIONAL EFFECTS OF HEPARIN‐BINDING PROTEIN HBp17 ON DNA SYNTHESIS IN CELLS
A 17kD heparin‐binding protein (HBp17) has a biphasic dose‐dependent effect on DNA synthesis in 3T3 cells. Maximal stimulation of DNA synthesis occurs at 8ng/ml HBp17, but a half‐maximal inhibition occurs at ∼500ng/ml. This inhibition can easily be reversed by addition of 400pg/ml aFGF or 100pg/ml bFGF, whereas EGF had no effect. This biphasic action of HBp17 was also seen in human umbilical vein endothelial cells (HUVEC), whereas it was not found in the malignant cell line, A431‐AJC. The functional relationship between HBp17 and FGF is discussed.
- Nanjing University China (People's Republic of)
- Nanjing University China (People's Republic of)
- W. Alton Jones Cell Science Center United States
DNA Replication, Umbilical Veins, Skin Neoplasms, Epidermal Growth Factor, Intracellular Signaling Peptides and Proteins, 3T3 Cells, Mice, Tumor Cells, Cultured, Animals, Fibroblast Growth Factor 1, Humans, Intercellular Signaling Peptides and Proteins, Fibroblast Growth Factor 2, Endothelium, Vascular, Carrier Proteins, Cell Division
DNA Replication, Umbilical Veins, Skin Neoplasms, Epidermal Growth Factor, Intracellular Signaling Peptides and Proteins, 3T3 Cells, Mice, Tumor Cells, Cultured, Animals, Fibroblast Growth Factor 1, Humans, Intercellular Signaling Peptides and Proteins, Fibroblast Growth Factor 2, Endothelium, Vascular, Carrier Proteins, Cell Division
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