Targeting SARS‐CoV‐2 viral proteases as a therapeutic strategy to treat COVID‐19
Copyright policy )Targeting SARS‐CoV‐2 viral proteases as a therapeutic strategy to treat COVID‐19
AbstractThe 21st century has witnessed three outbreaks of coronavirus (CoVs) infections caused by severe acute respiratory syndrome (SARS)‐CoV, Middle East respiratory syndrome (MERS)‐CoV, and SARS‐CoV‐2. Coronavirus disease 2019 (COVID‐19), caused by SARS‐CoV‐2, spreads rapidly and since the discovery of the first COVID‐19 infection in December 2019, has caused 1.2 million deaths worldwide and 226,777 deaths in the United States alone. The high amino acid similarity between SARS‐CoV and SARS‐CoV‐2 viral proteins supports testing therapeutic molecules that were designed to treat SARS infections during the 2003 epidemic. In this review, we provide information on possible COVID‐19 treatment strategies that act via inhibition of the two essential proteins of the virus, 3C‐like protease (3CLpro) or papain‐like protease (PLpro).
- University of Illinois at Chicago United States
- Center for Agricultural Resources Research United States
- University of Illinois at Chicago United States
- USDA , Agricultural Research Service United States
- University of Chicago United States
SARS-CoV-2, Viral Proteases, COVID-19, Coronavirus Papain-Like Proteases, Viral Nonstructural Proteins, Antiviral Agents, COVID-19 Drug Treatment, Infectious Diseases, Virology, Middle East Respiratory Syndrome Coronavirus, Humans, Protease Inhibitors, Coronavirus 3C Proteases
SARS-CoV-2, Viral Proteases, COVID-19, Coronavirus Papain-Like Proteases, Viral Nonstructural Proteins, Antiviral Agents, COVID-19 Drug Treatment, Infectious Diseases, Virology, Middle East Respiratory Syndrome Coronavirus, Humans, Protease Inhibitors, Coronavirus 3C Proteases
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