Major histocompatibility complex class I molecules are required for the development of insulitis in non‐obese diabetic mice
Copyright policy )Major histocompatibility complex class I molecules are required for the development of insulitis in non‐obese diabetic mice
AbstractAn early step in the development of autoimmune diabetes is lymphocyte infiltration into the islets of Langerhans of the pancreas, or insulitis. The infiltrate contains both CD4+ and CD8+ T cells and both are required for progression to diabetes in non‐obese diabetic (NOD) mice. It has been thought that the CD4+ lymphocytes are the initiators of the disease, the islet invaders, while CD8+ cells are the effectors, the islet destroyers. We question this interpretation because NOD mice lacking MHC class I molecules, hence CD8+ T cells, do not display even insulitis when expected.
Islets of Langerhans, Mice, Diabetes Mellitus, Type 1, Mice, Inbred NOD, CD8 Antigens, CD4 Antigens, Histocompatibility Antigens Class I, Animals, Lymphocytes
Islets of Langerhans, Mice, Diabetes Mellitus, Type 1, Mice, Inbred NOD, CD8 Antigens, CD4 Antigens, Histocompatibility Antigens Class I, Animals, Lymphocytes
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