In previous studies the extracellular adenosine has been proved as an important signaling molecule controlling dynamics of the immune response in Drosophila melanogaster. In mammals the adenosine signaling and control is more complex process. Since there is a certain genetic and evolutionary conservation between mammals and invertebrates, Drosophila represents simple system how to study such a complex regulation in vivo. Mutations of adenosine receptor in all cells as well as downregulation of ENT2 in immune cells caused decrease of resistance of the immune system against Drosophila parazitoid. The aim of the thesis is to determine whether RNAi targeted against mRNA of adenosine deaminase ADGF-A, which degrades e-Ado under natural conditions, would have any effect on immune response.