Drug-resistant infections have the potential to threaten tens of millions of lives, yet, in many countries, efforts to promote sustainable antimicrobial use and implement national action plans have stalled. As the antimicrobial resistance (AMR) threat grows, it is increasingly important to integrate scientific evidence into the national and global AMR responses. We propose to develop a Virtual Policy Think Tank that serves as a bridge between AMR science and policy, leverages global science and insights, and delivers relevant and rigorous evidence that responds to urgent global policy needs. The Think Tank will undertake three streams of work to build coordinated and innovative progress toward global AMR goals. A rapid response stream that responds to rapid evidence requests from governments and other actors will support the implementation of robust, evidence-informed AMR action plans. A capacity-building stream will support the regular use of scientific evidence in AMR policymaking processes. A policy proposal stream that engages academics from around the world will build new solutions for intractable AMR policy challenges. The Think Tank will act as a global leader and resource for evidence-informed AMR policy with the aim of ensuring sustainable antimicrobial use for all.