Qualitative and quantitative molecular genetic analysis of Catechol-O-methyltransferase (COMT) and Proline dehydrogenase (PRODH) genes in schizophrenia and related traits in a Chinese population.
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Qualitative and quantitative molecular genetic analysis of Catechol-O-methyltransferase (COMT) and Proline dehydrogenase (PRODH) genes in schizophrenia and related traits in a Chinese population This project aims to investigate an important resource for schizophrenia research, a sample of families with the illness including DNA and detailed clinical and neuropsychological information. 1. To attempt to replicate genetic association with schizophrenia and the Catechol-O-methyltransferase (COMT) and Proline dehydrogenase (PRODH) genes. 2. To use neuropsychological measures of cognitive abilities as endophenotypes in order to replicate association between COMT allele and performance of the Wisconsin Card Sorting test, and to further refine and understand these genetic associations.
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