Powered by OpenAIRE graph

Development of a synthetic flowable dressing that prevents corneal scarring

Funder: UK Research and InnovationProject code: MR/N019016/1
Funded under: MRC Funder Contribution: 2,258,770 GBP

Development of a synthetic flowable dressing that prevents corneal scarring

Description

Injuries caused by trauma, infections and inflammation to the surface of the eye can cause scarring that 'clouds' the transparent window of the eye called the cornea, interfering with vision and is sight-threatening. 'Corneal Blindness' affects millions of people and the World Health Organisation have made curing the problem a priority area programme to prevent world-wide blindness. The current treatment for damaged eyes caused by infection is to treat with antibiotic agents followed by strategies to promote healing. We are developing a synthetic, optically-transparent, anti-scarring dressing (biomembrane) suitable for the management of patients world-wide at risk of corneal scarring following injury, by promoting cells and molecules in tissues to heal without scarring improving patient visual outcomes. To date we have: (1), engaged closely with clinical colleagues to define and refine the characteristics and technical specifications of the fluid biomembrane dressing to ensure suitability for clinical use (2), investigated processes for its manufacture (3), performed limited testing of a dressing prototype (4), prepared a technical portfolio of the performance data generated thus far. We now seek further funding to allow progression of the project so that we can: (1), refine and improve the characteristics and performance of the dressing (2), scale-up its manufacture for use in humans (3), obtain regulatory approvals for testing in humans and finally (4), undertake a small clinical trial to check for safety and see how well the anti-scarring dressing works on patients with infected corneas. At this same time we will be (5), developing a commercialisation plan so that the new dressing becomes widely available for use in the clinic to reduce ocular scar formation that can cause blindness.

Data Management Plans
Powered by OpenAIRE graph

Do the share buttons not appear? Please make sure, any blocking addon is disabled, and then reload the page.

All Research products
arrow_drop_down
<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=ukri________::6c0efef49872c202bdc798d73a8b3f01&type=result"></script>');
-->
</script>
For further information contact us at helpdesk@openaire.eu

No option selected
arrow_drop_down