Synthetic biology is a new scientific discipline that aims to make the engineering of biological systems easier, more predictable and more reliable. Synthetic biologists aim to develop new techniques, technologies and reagents that will allow biological or biologically based products to be made easily, quickly and cheaply, and in sufficient quantities to make them useful. Advances in this area have the potential to provide us with new fuels, materials, diagnostics and medicines, and offer solutions to many of the major global challenges that we face today. For example providing sufficient food for the world's population and reducing our dependence on fossil fuels. For synthetic biology to meet these challenges, however, will require the concerted efforts of large groups of scientists working together in teams combining their expertise, skills and knowledge. To achieve this we aim to establish BrisSynBio (BSB), a Bristol-based Synthetic Biology Research Centre, which will bring together a group of scientists from a range of different research backgrounds, e.g. biology, chemistry, computer science, engineering and robotics, mathematics and physics. BSB researchers will combine their expertise in such a way that global challenges can be met and resolved. Examples of the type of work that BSB scientists will carry out include: modifying biosynthetic pathways in microorganisms such to produce new antibiotics; assembling virus-like particles to present new routes to vaccines; building simple cells from scratch for use in the production of important but sometimes toxic chemicals; using red blood cells to deliver complex molecules like anti-cancer drugs directly to tumours; and reprograming bacteria to perform useful tasks like sensing environmental pollutants. Within the BSB, researchers will be organised into teams with complementary skills who will work together on these challenging projects. There will be lots of communication between the teams, and new and exciting research will emerge as a result. Teams will be linked together by cross-cutting themes to promote interdisciplinarity and exchange of ideas. To help foster and develop interactions further, BSB academics will attend monthly discussion meetings, and all BSB academics and researchers will attend monthly research seminars and an annual 2-day regional symposium. The University of Bristol has recently invested heavily in new buildings and laboratory space, perfect for housing BSB. Now we need further investment to purchase the essential equipment that we will need to underpin and progress our research, and also to attract more scientists to expand synthetic-biology activities. We will also work in collaboration with a range of different project partners including researchers form around the world, the public and policy makers, and industrialists, such that we can maximise the impact of BrisSynBio. Finally, synthetic biology is not without controversy, the notion of tinkering with biology and life does not sit comfortably with everyone. Therefore, it is very important that all BrisSynBio members are trained to consider the ethical, legal and social implications of their work, placing it in a broader societal context. To achieve this BSB members will be trained in responsible innovation and public engagement, and encouraged to put these new skills into practice through commercialising their work where appropriate, and at 6-monthly science cafes and public dialogues.