Dissecting evolutionary and molecular patterns governing human embryonic development
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Pluripotent cells have the capacity to form any cell of the body, including tissues present during embryonic development only: the placenta, amnion and yolk sac (extra-embryonic cells). By activating specific genes in pluripotent cells with CRISPR-Cas tools, we successfully generated extra-embryonic cell types in a dish. The specialization of extra-embryonic cells was examined by testing activation of multiple gene sets. Next, we over-activated genes involved embryo development, investigating how mis-regulation of genes in certain cells may lead to developmental errors. The study increase our knowledge of early fetal development, and can contribute to understanding why problems may occur during pregnancy.
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