Identification of proteins that inactivate the female X chromosome
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During embryonic development in mammals, female cells silence one of the two X chromosomes in a process called X-chromosome inactivation. In this project, we have applied powerful new labelling strategies to identify 41 proteins that are involved in X inactivation. Future functional studies are required to further explore the exact functions of these proteins in the X inactivation process. Thus, our all-encompassing approach revealed for the first time all proteins and protein complexes that cooperate in the silencing of the X chromosome, and thereby this project has been very successful.
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